70.3 Des Moines 2021 was delayed because of thunderstorms by two hours, consequently the bike was shortened.
Male Race Results
| Rank | Name | Nation | Swim | Bike | Run | Time | Prize Money |
| 1 | Jason West | USA | 00:24:25 | 00:59:12 | 01:09:35 | 02:38:20 | US$ 4,000 |
| 2 | Collin Chartier | USA | 00:24:32 | 00:59:24 | 01:10:16 | 02:39:42 | US$ 2,750 |
| 3 | Jackson Laundry | CAN | 00:26:11 | 00:58:31 | 01:11:19 | 02:41:30 | US$ 2,000 |
| 4 | Joe Gambles | AUS | 00:26:03 | 00:58:26 | 01:12:15 | 02:42:32 | US$ 1,750 |
| 5 | Mauricio Mendez Cruz | MEX | 00:24:32 | 01:00:07 | 01:12:17 | 02:42:40 | US$ 1,500 |
| 6 | Brennen Smith | CAN | 00:24:28 | 00:59:37 | 01:14:10 | 02:43:28 | US$ 1,250 |
| 7 | Robbie Deckard | USA | 00:26:02 | 00:59:52 | 01:13:19 | 02:45:17 | US$ 1,000 |
| 8 | Brock Hoel | CAN | 00:24:26 | 00:59:23 | 01:16:24 | 02:45:55 | US$ 750 |
| 9 | Nicholas Chase | USA | 00:26:59 | 00:59:27 | 01:14:09 | 02:46:21 | |
| 10 | Andre Lopes | BRA | 00:25:58 | 01:00:23 | 01:14:26 | 02:46:42 | |
| 11 | Eric Lagerstrom | USA | 00:24:24 | 00:59:23 | 01:19:21 | 02:48:48 | |
| 12 | TJ Tollakson | USA | 00:25:40 | 00:58:28 | 01:19:04 | 02:49:35 | |
| 13 | Martin Ulloa | CHI | 00:24:32 | 00:58:35 | 01:22:46 | 02:51:17 | |
| 14 | Garrick Loewen | CAN | 00:25:37 | 01:00:22 | 01:20:26 | 02:52:54 | |
| 15 | Robby Webster | USA | 00:28:56 | 01:04:28 | 01:14:43 | 02:53:49 | |
| 16 | Tyson Wieland | USA | 00:27:44 | 01:05:42 | 01:15:32 | 02:54:14 | |
| 17 | Nicholas Marcantonio | USA | 00:29:30 | 01:00:05 | 01:18:02 | 02:54:34 | |
| 18 | Marty Andrie | USA | 00:25:34 | 01:05:22 | 01:17:19 | 02:54:49 | |
| 19 | Erik Peterson | USA | 00:28:29 | 01:04:35 | 01:16:11 | 02:55:56 | |
| 20 | Kevin Collington | USA | 00:25:59 | 01:03:49 | 01:20:59 | 02:56:44 | |
| 21 | Ted Treise | USA | 00:28:41 | 01:02:10 | 01:21:10 | 02:58:23 | |
| 22 | Mikael Staer Nathan | CAN | 00:28:50 | 01:02:42 | 01:21:04 | 02:58:35 | |
| 23 | Hunter Lussi | USA | 00:26:18 | 01:03:56 | 01:22:22 | 02:59:33 | |
| 24 | Paul Stevenson | USA | 00:27:46 | 01:02:54 | 01:23:11 | 02:59:58 | |
| 25 | Travis Wood | USA | 00:29:00 | 01:01:44 | 01:25:48 | 03:02:55 | |
| 26 | Andy Krueger | USA | 00:26:10 | 01:06:00 | 01:23:41 | 03:02:56 | |
| 27 | Scott Haeberle | USA | 00:24:36 | 01:02:31 | 01:33:47 | 03:06:53 | |
| 28 | Adam Feigh | USA | 00:28:31 | 01:05:20 | 01:27:28 | 03:08:27 | |
| 29 | Steven Parker | USA | 00:29:30 | 01:10:41 | 01:23:09 | 03:08:59 | |
| 30 | Pablo Gomez | COL | 00:29:01 | 01:05:32 | 01:30:25 | 03:12:26 | |
| 31 | Javier Hidalgo | ESP | 00:36:05 | 01:06:54 | 01:26:45 | 03:17:43 | |
| Evan Price | USA | 00:31:49 | 01:03:18 | DNF | |||
| Matt McWilliams | USA | 00:29:58 | DNF |
Female Race Results
| Rank | Name | Nation | Swim | Bike | Run | Time | Prize Money |
| 1 | Holly Lawrence | GBR | 00:25:42 | 01:04:03 | 01:18:07 | 02:53:45 | US$ 4,000 |
| 2 | Emma Pallant-Browne | GBR | 00:27:23 | 01:05:24 | 01:16:54 | 02:55:25 | US$ 2,750 |
| 3 | Jackie Hering | USA | 00:28:12 | 01:04:17 | 01:18:30 | 02:57:07 | US$ 2,000 |
| 4 | Jeanni Metzler | ZAF | 00:26:36 | 01:05:59 | 01:23:46 | 03:02:33 | US$ 1,750 |
| 5 | Lesley Smith | USA | 00:28:40 | 01:08:39 | 01:18:56 | 03:03:01 | US$ 1,500 |
| 6 | Alissa Doehla | USA | 00:28:34 | 01:06:22 | 01:23:37 | 03:05:17 | US$ 1,250 |
| 7 | Grace Alexander | USA | 00:26:30 | 01:07:01 | 01:29:39 | 03:09:43 | US$ 1,000 |
| 8 | Mollie Hebda | USA | 00:28:12 | 01:08:05 | 01:27:04 | 03:10:24 | US$ 750 |
| 9 | Lisa Becharas | USA | 00:28:49 | 01:05:59 | 01:32:01 | 03:13:03 | |
| 10 | Jessica Smith | USA | 00:28:47 | 01:08:10 | 01:29:36 | 03:13:18 | |
| 11 | Danielle Treise | USA | 00:30:47 | 01:11:49 | 01:29:03 | 03:18:42 | |
| 12 | Sierra Snyder | USA | 00:30:22 | 01:10:57 | 01:30:45 | 03:19:21 | |
| 13 | Elizabeth James | USA | 00:35:53 | 01:09:18 | 01:27:15 | 03:19:44 | |
| 14 | Maddy Pesch | USA | 00:30:44 | 01:09:29 | 01:40:22 | 03:27:48 | |
| 15 | Sarah Karpinski | USA | 00:35:05 | 01:13:03 | 01:33:37 | 03:29:04 | |
| 16 | Amy Vantassel | USA | 00:33:04 | 01:14:57 | 01:34:46 | 03:30:17 | |
| 17 | Haley Koop | USA | 00:35:01 | 01:09:30 | 01:39:41 | 03:30:42 | |
| 18 | Laura Mathews | USA | 00:30:47 | 01:14:51 | 01:52:20 | 03:46:58 | |
| Ali Brauer | USA | 00:26:24 | 01:05:27 | DNF | |||
| Rachel Olson | USA | 00:26:24 | 01:10:49 | DNF | |||
| Tamara Jewett | CAN | 00:30:16 | 01:08:48 | DNF | |||
| Brittany Higgins | USA | 00:30:49 | 01:10:48 | DNF | |||
| Alycia Hill | USA | 00:30:47 | 01:12:18 | DNF | |||
| Kate Vermann | USA | 00:30:38 | 01:16:17 | DNF | |||
| Molly Lohry | USA | 00:31:32 | DNF |